Officers were called to the 200 block of Penn Street, where they found 48-year-old Carlos Rodriguez with a gunshot wound to the leg around 2:30 a.m., Reading police said.
Rodriguez was taken to Reading Hospital for treatment, according to police.
Gunfire reportedly broke out after an argument between Rodriguez and two other men in the 300 block of Penn Street.
The argument became physical, and when Rodriguez tried to flee, one of the men shot him, according to police.
The two alleged suspects fled soon after.
Anyone with additional information on the incident is asked to contact the Reading Police Criminal Investigations Division at 610 -655-6246 or Crime Alert Berks County 877-373-9913.
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